Motor activity of stomach and duodenum while blocking NO-ergic system

  • O. O. Galyns’ky Oles Honchar Dnipropetrovsk National University
  • A. S. Trushenko Dnipropetrovsk State Medical Academy Research Institute of Gastroenterology of Academy of Medical Sciences of Ukraine
  • V. O. Galyns’ky Oles Honchar Dnipropetrovsk National University
  • O. V. Severynovs’ka Oles Honchar Dnipropetrovsk National University
  • A. I. Rudenko Oles Honchar Dnipropetrovsk National University


The features of ultradian rhythms of the stomach and duodenum of rats under different time spans of blocking NO-synthase and the associated disturbance of regulatory mechanisms have been investigated. The functional relationship between changes in the МEA of stomach and duodenum, as well as the morphological status of the mucous membrane under disturbance of the nitric monoxide synthesis have been established. Each time blocking NO-ergic system caused an increase in motor performance index of the stomach and duodenum by 16.8 % and 42.4 % respectively (p < 0.05). On the sixth day of the NO deficiency, the motor index was noted to increase 1.5 times (p < 0.05), the duodenum rhythm imposed on stomach. It was accompanied by the duodenogastric reflux. On the twelfth day of NO deficit the reduction of the stomach and duodenum motor indices was noted, as compared with a control. It indicated exhaustion of adaptive-compensatory mechanisms. It is advisable to use of data obtained in the pathophysiology and in the medical practice.


1. Абасова А. С. Динамика содержания оксида азота в желудочном соке у больных с кислотозависимыми заболеваниями желудка и двенадцатиперстной кишки: Автореф. дисс. … канд. мед. наук. – Махачкала, 2009. – 26 с.
2. Ивашкин В. Т. Клиническое значение оксида азота и белков теплового шока / В. Т. Ивашкин, О. М. Драпкина. – М. : Гэотар-Медиа, 2001. – 84 с.
3. Трушенко О. С. Міоелектрична активність шлунка та дванадцятипалої кишки при ушкодженні гастродуоденальної ділянки / О. С. Трушенко, О. Б. Мурзін, А. І. Руденко // Фізіологічний журнал. – 2006. – Т. 52, № 2. – С. 169.
4. Щербак В. А. Содержание метаболитов оксида азота в крови и желудочном соке у детей с хроническим дуоденитом // Вопросы современной педиатриии. − 2007. − Т. 6, № 6. – С. 54–57.
5. Gastroprotective and blood pressure lowering effects of dietrary nitrate are abolished by anmuthwash / J. Petersson, M. Carlstrom, O. Schreiber et al. // Biol. Med. − 2009. − Vol. 46, N 8. – Р. 1068−1075.
6. Konturek J. W. Endogenous nitric oxide in the regulation of gastric secretory and motor activity in humans / J. W. Konturek, H. Fischer, P. M. Gromotka // Aliment Pharmacol Ther. – 1999. – Vol. 13. – P. 1683–1691.
7. Nitric oxide is involved in heat-induced HSP70 accumulation / L. Y. Malyshev, E. B. Manukhina, V. D. Mikoyan et al. // FEBS Lett. − 1995. − Vol. 370. − P. 159−162.
8. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness / H. Björne, J. Petersson, M. Phillipson et al. // J. Clin. Invest. – 2004. – Vol. 113, N 1. – P. 106−114.
9. Ozmeric N. Advnces in peroriodontal disease markers // Clin. Chim. Acta. − 2004. – Vol. 343, N 1−2. – Р. 50.
10. Sivarao D. V. Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: Animal models of gastroparesis and duodenogastric reflux / D. V. Sivarao, H. Mashimo, R. K. Goyal // Gastroenterology. – 2008. – Vol. 135, N 4. – P. 1258−1266.

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