Nitric oxide synthase activity and peroxynitrite content in cells of rat’s mucous coat of stomach under experimental stress-induced ulcer


  • I. S. Maksymovych Taras Shevchenko Kyiv National University
  • M. V. Mylenko Taras Shevchenko Kyiv National University
  • O. V. Drobinska Taras Shevchenko Kyiv National University
  • L. I. Ostapchenko Taras Shevchenko Kyiv National University

Abstract

Nitric oxide synthase activity in gastric mucosal cells as well as peroxynitrite generation in experimental stress-induced gastric ulcer formation in rats were studied. There was made the conclusion that nitric oxide synthase activity is growing during the stress. It causes increasing of peroxynitrite’ production and ulcer formation. It was established that destructive gastric mucosal damages depend on stress’ duration. It was determined that nitric oxide is involved in complex pathogenetic mechanisms of ulceration.

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Published
2009-02-20
Section
Articles