Comparative research of the influence of local anesthetics on a spinal cord

  • O. O. Shugurov Oles Honchar Dnipropetrovsk National University
  • O. Y. Sorokina Dnipropetrovsk State Medical Academy
  • O. A. Shugurov Oles Honchar Dnipropetrovsk National University

Abstract

Development of neuron’s depression subject to time after influence of local anesthetics (lidocaine, novocaine and bupivacaine) on a spinal cord or nerve in equal concentrations was experimentally studied in cats. Depressing neuronal activity has the different dynamics depending on presence of influence on a spinal cord/nerve and on the anesthetic kind. The AS changes had the same tendency to oppression as CDP components. It is judged that for practical purposes it is necessary to use combinations of preparations of the various characteristics of temporary depressing activity of neurons.

References

Дія лідокаїну, клофеліну та дімедролу, що прикладені до поверхні спинного мозку, на його викликану біоелектричну активність / В. Т. Мамчур, С. І. Забашний, Т. А. Краюшкіна, Т. В. Холодницький // XIV з’їзд Українського фізіол. товариства. Тези доповідей. – К.: 1994. – С. 60.

Ефанова С. Г. Исследование происхождения поздних негативных компонентов потенциала дорсальной поверхности спинного мозга кошки / С. Г. Ефанова, О. А. Шугуров, О. О. Шугу¬ров // Социально-медицинские аспекты охраны здоровья. – Д.: Днiпро, 1995. – С. 74–75.

Кияткин Е. А. Нейрофизиология и нейрохимия процессов, связанных с болью и аналгезией / Е. А. Кияткин, Ю. В. Буров // Изв. АН СССР. Сер. биол. – 1987. – № 1. – С. 119–134.

Ургалиев Ж. Ш. Оценка боли посредством вызванных потенциалов мозга / Ж. Ш. Ургалиев, Е. Е. Мейзеров // Актуал. проблемы современ. биол. – Алма-Ата: Мин-во нар. образ. КазССР, 1991. – С. 57–58.

Bonica J. J. Advanced in pain research and therapy / J. J. Bonica, J. C. Liebeslind, D. G. Athe-Fessard – New York: Raven Press, 1978. – Vol. 3. – 956 p.

Cutaneous responsiveness of lumbar spinal dorsal horn neurons is reduced by general anesthesia, an effect dependent in part on GABAA mechanisms / K. Ota, T. Yanagidani, K. Kishikawa et al. // J. Neurophysiol. – 1998. – Vol. 80, N 3. – Р. 1383–1390.

Effects of pentobarbital on heterosegmentally activated dorsal root depolarization in the rat. Investigation by sucrose-gap technique in vivo / K. Shimoji, N. Fujiwara, S. Denda et al. // Anesthesiology. – 1992. – Vol. 76, N 6. – P. 958–966. >> doi:10.1097/00000542-199206000-00015

Electrophysiological properties of lumbar motoneurons in the alpha-chloralose-anesthetized cat during carbachol-induced motor inhibition / M. C. Xi, R. H. Liu, J. Yamuy et al. // J. Neurophysiol. – 1997. – Vol. 78, N 1. – P. 129–136.

LaBella F. S. Is there a general anesthesia receptor? // Can. J. Physiol., Pharmacol. – 1981. – Vol. 59, N 5. – P. 432–442.

Levy R. A. Presynaptic control of input to the central nervous system // Can. J. Physiol., Pharmacol. – 1980. – Vol. 59, N 7. – P. 751–766. >> doi:10.1139/y80-119

Li R. Spinal evoked potential P–wave elicited by C fiber input and depressed by analgetic factors / R. Li, Y. X. Yu // Neuro Report. – 1991. – Vol. 2, N 4. – P. 205–207.

Mongan P. D. Intravenous anesthetic alterations on the spinal-sciatic evoked response in swine / P. D. Mongan, R. E. Peterson // Anesth Analg. – 1993. – Vol. 77, N 1. – Р. 149–154.

Raja S. N. Peripheral mechanisms of somatic pain / S. N. Raja, R. A. Meyer // Anesthesiology. – 1988. – Vol. 68, N 4. – P. 571–590. >> doi:10.1097/00000542-198804000-00016

Spinal cord potentials evoked by cutanecus afferents in the monkey / J. E. Beall, A. E. Applebaum, R. D. Foreman, W. D. Willis // J. Neurcphysic. – 1977. – Vol. 40, N 2. – P. 199–211.

Tabatabai M. Effects of lidocaine and bupivacaine on electrophysiological properties of the nerve cells in rat / M. Tabatabai, A. M. Booth // Anesthesiology. – 1988. – Vol. 69, N 3A, Suppl. – P. 864. >> doi:10.1097/00000542-198809010-00864

Weisenberg M. Pain and pain control // Psychological Bull. – 1977. – Vol. 84, N 5. – P. 1008–1044. >> doi.org/10.1037/0033-2909.84.5.1008

Published
2006-01-15
Section
Articles