Age-related changes in morphofunctional properties of Mucus and Enteral nervous system of gastrointestinal tract in Mammals


  • D. D. Zhernosekov Oles Honchar Dnipropetrovsk National University
  • A. S. Trushenko Dnipropetrovsk State Medical Academy Research Institute of Gastroenterology of Academy of Medical Sciences of Ukraine
  • A. I. Rudenko Oles Honchar Dnipropetrovsk National University

Abstract

In the review questions of changes of mucus structure and protective properties of mucosa as well as those of enteric nervous system (ENS) of mammalian gastrointestinal tract are discussed at aging. The resulted experimental and clinical data testify to presence of the various mechanisms providing reparative properties of mucosa. Enlarged susceptibility of mucosa to disturbing factors observed with the years is connected with changes of mucosal prostaglandins amount. Neurodegenerative processes in ENS strengthen with the years, thus various types of neurones are exposed to various kinds of degenerative changes. The causes of the latter remain insufficiently investigated by the present time. 

References

Л. А. Структура и функции гликопротеинов слизи (муцинов) // Рос. ж. гастроэнтер., гепатол., колопрокт. – 1998. – № 1. – С. 30–37.
2. Коркушко О. В. Трансформація шлункової секреції при фізіологічному старінні людини (базальна секреція) / О. В. Коркушко, Д. М. Якименко // Сучасна гастроентерологія. – 2002. – № 3. – С. 7–12.
3. Aging diminishes gastric mucosal regeneration: relationship to tyrosine kinases / S. E. Fligiel, N. K. Relan, S. Dutta et al. // Lab. Invest. – 1994. – Vol. 70. – P. 764–774.
4. Allen A. Gastroduodenal mucus bicarbonate barrier: protection against asid and pepsin / A. Allen, G. Flemstrom // Am. J. Physiol. Cell. Physiol. – 2005. – Vol. 288. – P. C1–C19.
5. Cyclooxygenase-1 and alternatively spliced mRNA in the rat stomach: effects of aging and ulcers / D. Vogiagis, E. M. Glare, A. Misajon et al. // Am. J. Physiol. Gastrointest. Liver Physiol. – 2000. – Vol. 278. – P. 820–827.
6. Developmental changes in gastric mucus gel thickness: responsiveness to 16,16-dimethyl prostaglandin E2 and mucosal protection in the rat / M. Tabata, T. Tomomasa, K. Itoh et al. // Pediatr. Res. – 1992. – Vol. 31, N 2. – P. 193–195.
7. Differential expression of EGFR during early reparative phase of the gastric mucosa between young and aged rats / L. Lin, I. R. Turner, Y. Yu et al. // Am. J. Physiol. Gastrointest. Liver Physiol. – 1998. – Vol. 275, N 5. – P. 943–950.
8. Gershon M. D. Functional anatomy of the enteric nervous system / M. D. Gershon, A. L. Kirchgessner, P. R. Wade // Physiology of the Gastrointestinal tract / Ed. L. R. Johnson. – New York: Raven, 1987. – P. 381–422.
9. Hosoda S. Age-related changes in the gastrointestinal tract / S. Hosoda, T. Bamba, S. Nakado // Nutr. Rev. – 1992. – Vol. 50, N 1. – P. 374–377.
10. Induction of EFG-receptor tyrosine kinase during early reparative phase of gastric mucosa and effects of aging / N. K. Relan, S. E. G. Fligiel, S. Dutta et al. // Lab. Invest. – 1995. – Vol. 73. – P. 717–726.
11. Lee M. Age-related reductions in gastric mucosal prostaglandin levels increase susceptibility to aspirin-induced injury in rats / M. Lee, M. Feldman // Gastroenterology. – 1994. – Vol. 107. – P. 1746–1750.
12. Majumdar A. P. Gastric mucosal tyrosine kinase activity during aging and its relationship to cell proliferation in rats / A. P. Majumdar, E. A. Edjerton, F. L. Arlow // Biochim. Biophys. Acta. – 1988. – Vol. 965, N 3. – P. 97–105.
13. Majumdar A. P. Gastric mucosal injuri and repair: effect of aging / A. P. Majumdar, S. E. Fligiel, R. Jarzewski // Histol. Histopathol. – 1997. – Vol. 12. – P. 491–501.
14. Modlin I. M. Acid related diseases: Biology and Treatment / I. M. Modlin, G. Sachs. – Schnetztor, D-Konstanz, 1998. – 368 p.
15. Morphologic changes in gastric mucosa of aging rats / D. Hollander, A. Tarnawski, I. Stachura, H. Sergely // Dig. Dis. Sci. – 1989. – Vol. 34, N 11. – P. 1692–1700.
16. Phillips R. J. Aging of the myenteric plexus: neuronal loss is specific to cholinergic neurons / R. J. Phillips, E. J. Kieffer, T. L. Powley // Auton. Neurosci. – 2003. – Vol. 106, N 2. – P. 69–83.
17. Santer R. M. Enteric neuron numbers and sizes in Auerbach’s plexus in the small and large intestine of adult and aged rats / R. M. Santer, D. M. Baker // J. Auton. Nerv. Syst. – 1988. – Vol. 25. – P. 59–67.
18. Silen W. Gastric mucosal defence and repair / Physiology of the Gastrointestinal tract / Ed. L. R. Johnson. – New York: Raven, 1987. – P. 1055–1069.
19. Wade P. R. Aging and neural control of the gastrointestinal tract // Am. J. Physiol. Gastrointest. Liver Physiol. – 2002. – Vol. 2835, N 3. – P. 489–495.
20. Werther J. L. The gastric mucosal barrier // The Mount Sinai J. Med. – 2000. – Vol. 67, N 1. – Р. 41–53.
Published
2006-01-05
Section
Articles