The Role and place of apoptosis in the antiphospholipide syndrome pathogenesis

  • O. S. Voronkova Oles Honchar Dnipropetrovsk National University


This article is devoted to the problem of mechanism study of the antiphosphoiipide syndrome development. Nowadays there is no single mention of that issue. The purpose of our work is the data examination and generalization about the apoptosis place and role in APLS pathogenesis and about antibody antiphosphoiipide participation in this process as mediators of autoimmune development, vascular and obstetrics pathology.


1. Агаджанова А. А. Современные подходы к диагностике и лечению АФС при невынашивании беременности // Вестник Российской ассоциации акушеров-гинекологов. - 1999,-№2. -С. 37^8.
2. Лушников Е. Ф. Гибель клетки (апопггоз) / Е. Ф. Лушников, А. Ю. Абросимов. - М.: Медицина, 2001.
3. Решетник Т. М. АФС: серологические маркеры, критерии диагностики, клинические проявления, классификации, прогноз / Т. М. Решетняк, 3. С. Алекберова // Терапевтический архив. - 1998. - №12. - С. 74-78.
4. Cancer Medicine / D. W. Kufe, R. E. Pollock, R. R. Weichselbaum, R. C. Jr. Bast, T. S. Gamier.— Hamilton (Canada): BC Decker Inc., 2003.
5. Cook M. C. В-cell biology, apoptosis and autoantibodies to phospholipides // Thrombosis research. - 2004. - 114 (5-6). - P. 307-319.
6. Dieude M. Induction of endothelial cell apoptosis by heat-shock protein 60-reactive antibodies from antiendothelial cell autoantibodypositive systemic lupus erythematosus patients / M. Dieude, J. L., Senecal, Y. Raymond // Arthritis Rheumatology. - 2004. - Oct. 8, 50(10).-P.3221-3231.
7. Janeway C. A. Immunobiology. The immune system in health and disease / C. A. Janeway,
P. Trayers, M. Walport, M. Schlomchic.—New-York: Garland publication, 2001.
8. Manfredi A. A. Apoptotic cell clearance in systemic lupus erythematosus. I. Opsonization by antiphospholipide antibodies / A. A. Manfredi, P. Rovere, G. Galati, etc. // Arthritis Rheumatology. - 1998. - Feb. 41(2). - P. 205-214.
9. Manfredi A. A. Apoptotic cell clearance in systemic lupus erythematosus, II. Role of 62-glycoprotein-1 / A. A. Manfredi, P. Rovere, S. Heltai, etc. // Arthritis Rheumatology. - 1998. - Feb. 41(2).-P, 215-223.
10. Mansen J. J. Antiphospholipide syndrome 7 J. J. Mansen, D. A. Isenberg // International journal of Biochem and celll biology. - 2003. - Jul. 35 (7). - P. 1015 - 1020.
11. Pitteni V. Apoptosis and antiphospholipide antibodies / V. Pitteni, D. Isenberg // Seminar arthritis Rheumatology..- 1998. - Dec, 28(3).- P. 163-178. к
12. Rauch J. Apoptosis and the antiphospholipide syndrome / J. Rauch, R. Su&ang, P. D’Aquill,
J. S. Koh, J. A. Levine // Autoimmunity. - 2000. - Sep. 15 (2). - P. 231-235.
13. Rebmann V. Soluble HLA-DR and soluble CD95 ligand levels in pregnant women with antiphospholipide syndrome / V. Rebmann, Ё. Ronin-Walknovska, O. Sipak-Szmigiel, A. Mikla- szewicz, E. Czajkowska, H. Gross-Wilde // Tissue Antigens. - 2003. - Dec. 62 (16). - P. 536- 541.
14. So rice M. Cardiolipine on the surface of apoptotic cells as a possible trigger for antiphospholipide antibodies / M. Sorice, A. Circella, R. Misasi, V. Pitteni, T. Garofalo, A. Cirelli, A. Pavan, G. M. Pontieri, G. Valesini // Clinical experimental immunology. - 2000. -Nov. 122(2).-P.277-284.

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