Bioinformatic approach to correction of negative emotional state in rats


  • D. A. Bevzyuk State Institution “Institute of Neurology, Psychiatry and Narcology of the NAMS of Ukraine”
  • N. A. Levicheva State Institution “Institute of Neurology, Psychiatry and Narcology of the NAMS of Ukraine”
Keywords: aggressive behavior, biopotentials, ventromedial hypothalamus, EEG

Abstract

One of the most important problems of modern society is the growth of aggression which leads to crimes, sadism, violence and other antisocial actions. Therefore, the study of the mechanisms of development of aggressive behavior and negative aggressive reactions is extremely urgent. Thus, in order to correct the aggressive behavior it is extremely important to develop new methodological approaches. Previous studies have shown that the brain biopotentials provide functional transfer of information. With the help of magnetic or other information carrier, the information can be stored and transmitted remotely from the donor to the recipient and, in that way, can control the behavior of the animal body. Using of biological programs, expressed via the brain biopotentials at their minimum voltage (which is indicated by the amplitude of the frequency spectrum of electrical oscillations in the EEG), it can give therapeutic effect. The aim of the paper is studying of the neurobiological mechanisms of aggressive behavior and usage of bioinformatic programs expressed via the potentials of the brain. In the course of the experiments, we have shown the possibility to use the ventromedial hypothalamic stimulation as a realistic model of negative emotional state. In this model, behavioral indexes (reactions of avoidance, increased vocalizations, negative grooming) correlated with the indexes of electrical activity of brain structures of emotional limbic-neocortical system (numerous epileptiform paroxysms, sharp shocks and complexes with epi components of peak-theta and peak-delta type). The introduction of information expressed in biopotentials of the positive emotional ventrolateral hypothalamus of the brain of donor rat to recipient rats with a model negative emotional state leads to balancing of emotional homeostasis, resulting in disappearance of convulsive components and diffuse affective paroxysms in EEG, and also in manifestations of positive grooming and tranquility. This method of emotional homeostasis correction is suggested as a new method for correction of emotional disorders and is expected to be effective for the further study. 

References

Avdeyenok, L.N., 2010. Psihologicheskie determinanty formirovanija agressivnogo povedenija u muzhchin [Psychological determinants offorming of aggressive behavior for men]. Sibirskij Vestnik Psihiatrii i Narkologii 3, 53–55 (in Russian).
Bevzyuk, D.A., 2012. Nejrofiziologicheskie mehanizmy transformacii sociofobij v agressivnoe povedenie v uslovijah deprivacii gedonicheskogo povedenija [Neurophysioligical mechanisms of transformation of social phobias in aggressive behavior in the conditions of deprivation of hedonic behavior]. Ukrai’ns’kyj Visnyk Psyhonevrologii’ 20(3), 162 (in Ukrainian).
Bevzyuk, D.A., Kirillova, N.A., 2008. Rol’ ventromedial’nogo gipotalamusa i mindalividnogo kompleksa v mehanizmah formirovanija fobii i transformacii ee v agressivnoe povedenie u krys [Role of ventromedial hypothalamus and amigdal in the mechanisms of forming ofphobia and transformation of her in aggressive behavior for rats]. IV Mіzhn. Naukova Konferencіja «Psihofіzіologіchnі ta vіsceral’nі funkcії v normі і patologії prisvjachena 90-rіchchju vіd dnja narodzhennja P.G. Bogacha», 42–43 (in Ukrainian).
Bevzyuk, D.O., 2012. Nejrofiziologichni mehanizmy transformacii’ zoosocial’nyh fobij v agresyvnu povedinku u shhuriv za umov deryvacii’ i’hn’oi’ motyvacii’ do kanabinoi’div [Neurophysioligical mechanisms of transformation of zoosocial phobias in aggressive behavior for rats at the terms of derivate of their motivation to canabis]. Ukrai’ns’kyj Visnyk Psyhonevrologii’ 20(4), 27–31 (in Ukrainian).
Borisov, A.I., 2007. Psihofiziologicheskie predposylki zhestokogo (agressivnogo) povedenija [Psychophysiological preconditions of cruel (aggressive) behavior]. Vjatskij Medicinskij Vestnik 2, 123–125 (in Russian).
Buresh, Y., Petran, M., Zakhar, I., 1962. Jelektrofiziologicheskie metody issledovanija [Electrophysiological methods of research]. Publishing House of Foreign Literature, Moskow (in Russian).
Copyright certificate [Avtorskoe svidetel’stvo] № 908378, 1981. Sposob upravlenija povedeniem zhivotnogo organizma [Management method by behavior ofanimal organism].
Bakumenko, L.P., Verzin, I.I., Vorobyeva, T.M., Dabagyan, A.V., Kononenko, I.V., Leshchenko, A.G., Ilyuk, R.D., 2012. Pokazateli agressii i gneva pri zavisimostjah ot razlichnyh psihoaktivnyh veshhestv [Indexes of aggression and anger at dependences on different psychoactive substances]. Narkologija 8, 58–66 (in Russian).
Ivanov, O.V., Yegorov, A.Y., 2012. Agressija i suicidal’noe povedenie: nejropsihologicheskie aspekty [Aggression and suicidal behavior: neuropsihology aspects]. Nevrologicheskij Vestnik 3, 15–28 (in Russian).
Katsouni, E., Zarros, A., Skandali, N., Tsakiris, S., Lappas, D., 2013. The role of cholecystokinin in the induction of aggressive behavior: A focus on the available experimental data (review). Acta Physiol. Hung. 100(4), 61–77. >>doi.:10.1556/APhysiol.100.2013.4.1
Kirenskaya, A.V., 2006. Kriminal’noe agressivnoe povedenie u podrostkov s zaderzhannym psihicheskim razvitiem: Nejrofiziologicheskie faktory riska [Criminal aggressive behavior for teenagers with the detained psychical development: Neurophysiological factors of risk]. Rossijskij Psihiatricheskij Zhurnal 4, 46–52 (in Russian).
Krahé, B., Berger, A., 2013. Men and women as perpetrators and victims of sexual aggression in heterosexual and samesex encounters: A study of first-year college students in Germany. Aggressive Behav. 39(5), 391–404. >>doi.:10.1002/ab.21482
Kulikov, G.A., 1998. Nejrobiologicheskie osnovy vysshej nervnoj dejatel’nosti cheloveka (Illjuzii specifichnosti vysshej nervnoj dejatel’nosti cheloveka) [Neurobiological bases of higher nervous activity of man (Illusions of specificity of higher nervous activity of man)]. Sorosovskij Obrazovatel’nyj Zhurnal 6, 9–15 (in Russian).
Lübke, K.T., Pause, B.M., 2013. Sex-hormone dependent perception of androstenone suggests its involvement in communicating competition and aggression. Physiol. Behav. 123, 136–141.
Naumenko, V.S., Kozhemyakina, R.V., Plyusnina, I.Z., Popova, N.K, 2013. Agressija i reakcija akusticheskogo refleksa vzdragivanija u geneticheski predraspolozhennyh k agressii i neagressivnyh molodyh krys [Aggression and reaction of acoustic reflex of starting for genetically predispositioned to aggression and non-aggressive young rats]. Zhurnal Vysshej Nervnoj Dejatel’nosti im. I.P. Pavlova 63(4), 479 (in Russian).
Olds, J., Milner, P., 1954. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J. Comp. Physiol. Psychol. 47, 419–427. >>doi.:10.1037/h0058775
Petryuk, A.P., Kutko, I.I., Bevzyuk, D.A., Vorobyeva, T.M., 2007. Kliniko-nejropsihologicheskie i jelektrofiziologicheskie korreljaty agressivnogo povedenija u lic s nepsihoticheskimi psihicheskimi rasstrojstvami [Clinical-neuropsycho¬logical and electro-physiological correlations of aggressive behavior at persons with unpsychotic psychonosemas]. Psyhichne Zdorov’ja 14(1), 17–22 (in Ukrainian).
Samedov, A.A., Eldarova, N.N., Gasanzade, L.A., 2012. Agressija pri rasstrojstvah lichnosti [Aggression at disorders of personality]. Psihicheskie Rasstrojstva v Obshhej Medicine 3, 59–61 (in Russian).
Schutter, D.J., Harmon-Jones, E., 2013. The corpus callosum: A commissural road to anger and aggression. Neurosci. Biobehav. Rev. 37(10), 2481–2488. >>doi.:10.1016/j.neubiorev.2013.07.013
Seth, A., Gitter, P.J., Ewell, R.E., Guadagno, T.F., Stillman, R.F., 2013. Baumeister virtually justifiable homicide: The effects of prosocial contexts on the link between violent video games, aggression, and prosocial and hostile cognition. Aggressive Behav. 39(5), 346–354.
Sharma, M.K., Marimuthu, P., 2014. Prevalence and psychosocial factors of aggression among youth. Indian J. Psychol. Med. 36(1), 48–53. >> doi.:10.4103/0253-7176.127249
Shostakovich, B.V., 2005. Sovremennye podhody k diagnostike psihopaticheskih rasstrojstv [Modern going near diagnostics of psychopathy disorders]. Rossijskij Psihiatricheskij Zhurnal 3, 7–14 (in Russian).
Shostakovich, B.V., Leonova, O.V., 2004. Koncepcija limbicheskoj psihoticheskoj triggernoj reakcii i ee udebnopsihiatricheskoe znachenie (analiticheskij obzor). Rossijskij Psihiatricheskij Zhurnal 1, 60–68 (in Russian).
Shurtliff, Q.R., Murphy, P.J., Yeiter, J.D., Matocq, M.D., 2013. Experimental evidence for asymmetric mate preference and aggression: Behavioral interactions in a woodrat (Neotoma) hybrid zone. BMC Evol. Biol. 13, 220. >>doi.:10.1186/1471-2148-13-220
Van Beek, J., Vuijk, P.J., Harte, J.M., Smit, B.L., Nijman, H., Scherder, E.J., 2014. The factor structure of the brief psychiatric rating scale (expanded version) in a sample of forensic psychiatric patients. Int. J. Offender Ther. Comp. Criminol. (in press). >> doi.:10.1177/0306624X14529077
Vorobyeva, T.M., Bevzyuk, D.A., Kirillova, N.A., 2009. Rol’ jemociogennyh struktur mozga v mehanizmah formirovanija fobij i ih vozmozhnoj transformacii v agressivnoe povedenie u krys [Role of emotional structures of brain in the mechanisms of forming of phobias and their possible transformation in aggressive behavior for rats]. Psihicheskoe Zdorov’e 4, 46–51 (in Ukrainian).
Williams, C., South Richardson, D., Hammock, G.S., Janit, A.S., 2012. Perceptions of physical and psychological aggression in close relationships: A review. Aggress. Violent Beh. 17(6), 489–494. >> doi.:10.1016/j.avb.2012.06.005
Published
2014-05-02
Section
Articles